DOCK4 polyclonal, anti-human, mouse, rat

Background:
DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

Alternative Name:
DOCK4, KIAA0716, Dedicator of cytokinesis protein 4, Dock4, DOCK4, KIAA0716,

Application Dilution:
ICC:1:50-1:200
IHC:1:50-1:200
WB:1:500

Specificity: DOCK4 polyclonal antibody detects endogenous levels of DOCK4 protein.

Immunogen:
Peptide

MW: 225 kDa

Swiss-Prot: Q8N1I0(Human) P59764(Mouse) F1LZ81(Rat)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.