Dok-1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7103
Background:
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.
Alternative Name:
Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK1_HUMAN, Downstream of tyrosine kinase 1, p62(dok), P62DOK, pp62
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Dok-1 polyclonal antibody detects endogenous levels of Dok-1 protein.
Immunogen:
Recombinant full length Human Dok-1.
MW: ~ 62 kDa
Swis Prot.: Q99704
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF.
Alternative Name:
Docking protein 1 62kD, Docking protein 1, DOK 1, DOK1, DOK1_HUMAN, Downstream of tyrosine kinase 1, p62(dok), P62DOK, pp62
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: Dok-1 polyclonal antibody detects endogenous levels of Dok-1 protein.
Immunogen:
Recombinant full length Human Dok-1.
MW: ~ 62 kDa
Swis Prot.: Q99704
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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