DOK1 polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP7690a
Catalog Number: AC-AP7690a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB1759/RB1760
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB1759/RB1760
Applications: IHC-P, WB
Datasheet
Request Information
Background:
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Other Names:
Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Target/Specificity:
This DOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1.
Antigen Region:
9-39
Antigen Type: Synthetic Peptide
Gene Name: DOK1
Gene ID: 1796
Primary Accession: Q99704
NCBI Accession: NP_001184189.1;NP_001372.1
Other Accession: Q4QQV2; P97465; Q5EA84
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Other Names:
Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Target/Specificity:
This DOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1.
Antigen Region:
9-39
Antigen Type: Synthetic Peptide
Gene Name: DOK1
Gene ID: 1796
Primary Accession: Q99704
NCBI Accession: NP_001184189.1;NP_001372.1
Other Accession: Q4QQV2; P97465; Q5EA84
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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