DOK6 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP7659a
Background:
Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK6, a member of the p62 Dok family of intracellular adaptor molecules, promotes Ret-mediated neurite growth, and may have a role in brain development and/or maintainance Dok-6 is abundantly expressed in the fetal and adult brain and cerebellum, and is co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, and in the ureteric buds of the developing kidneys. DOK6 Interacts via its PTB domain with phosphorylated RET through an Src-dependent mechanism, indicating that DOK6 is a substrate of the Ret-Src signaling pathway.
Other Names:
Docking protein 6, Downstream of tyrosine kinase 6, DOK6, DOK5L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7659a was selected from the Center region of human DOK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DOK6
Gene ID: 220164
Primary Accession: Q6PKX4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK6, a member of the p62 Dok family of intracellular adaptor molecules, promotes Ret-mediated neurite growth, and may have a role in brain development and/or maintainance Dok-6 is abundantly expressed in the fetal and adult brain and cerebellum, and is co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, and in the ureteric buds of the developing kidneys. DOK6 Interacts via its PTB domain with phosphorylated RET through an Src-dependent mechanism, indicating that DOK6 is a substrate of the Ret-Src signaling pathway.
Other Names:
Docking protein 6, Downstream of tyrosine kinase 6, DOK6, DOK5L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7659a was selected from the Center region of human DOK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DOK6
Gene ID: 220164
Primary Accession: Q6PKX4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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