DPPA4 Polyclonal Antibody

Background:
This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Developmental biology, Stem cells

Synonyms:
2410091M23Rik, Developmental pluripotency associated 4, Developmental pluripotency associated protein 4, Developmental pluripotency-associated protein 4, Dppa 4, DPPA4, DPPA4, FLJ10713

Immunogen: Synthetic peptide of human DPPA4

Swissprot: Q7L190
Gene Accession: NP060659

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.56 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.