DPYD polyclonal, anti-human

Background:
The protein encoded by this gene is a pyrimidine catabolic enzyme. Involved in pyrimidine base degradation and catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms: DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase

Cellular Location: Cell membrane Cytoplasm 

Immunogen:
Recombinant protein of human DPYD

Gene Symbol: DPYD

Gene ID: 1806

Swiss prot: Q12882

Calculated MW: 111kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20°C. Avoid freeze / thaw cycles.