DR1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Synonyms: NC2, NC2B, NC2-BETA

Cellular Location: Nucleus

Immunogen:
A synthetic peptide of human DR1

Gene Symbol: DR1

Gene ID: 1810

Swiss prot: Q01658

Calculated MW: 19kDa

Recommended dilution:
IHC 1:20-100

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.