DR3/Apo3 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10043-100
Catalog Number: AC-ABV10043-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Background:
Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily thro µgh interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis thro µgh TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.
Other Names:
WAL-1, APO-3, TRAMP, LARD
Primary Accession: Q8VD70
Other Accession: AAH17526
Concentration (mg/ml): 0.5 mg/ml
Apoptosis can be induced by certain cytokines including TNF and Fas in the TNF superfamily thro µgh interaction with their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR3 (also called Wal-1, Apo3, TRAMP and LARD). The ligand for this novel death receptor has been defined as TWEAK (also termed Apo3L). Like TNFR1, overexpression of DR3 triggers apoptosis and NF-kB activation. Activation of DR3 results in recruitment of TRADD (a DD containing adapter molecule). TRADD associates with FADD, TRAF2, and RIP to activate the signaling complex for NF-kB activation. DR3 activates apoptosis thro µgh TRADD, FADD, and caspase-8. DR3 is highly expressed in the tissues enriched in lymphocytes including peripheral blood leucocytes (PBL), thymus and spleen.
Other Names:
WAL-1, APO-3, TRAMP, LARD
Primary Accession: Q8VD70
Other Accession: AAH17526
Concentration (mg/ml): 0.5 mg/ml
| Is Featured? | No |
|---|
Write Your Own Review