DR3 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
253302
Protein Family: Cellular Antigens, Receptors and Channels
Pathway and Disease: Cell Growth and Death, Immune System, Signal Transduction, Signaling Molecules and Interaction
Description:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
Alternate Names: Tumor necrosis factor receptor superfamily member 25, WSL-1 protein, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death domain receptor 3, WSL protein, Apoptosis-inducing receptor AIR, Apo-3, Lymphocyte-associated receptor of death, LARD, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: AAQ88676
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DR3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Growth and Death, Immune System, Signal Transduction, Signaling Molecules and Interaction
Description:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
Alternate Names: Tumor necrosis factor receptor superfamily member 25, WSL-1 protein, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death domain receptor 3, WSL protein, Apoptosis-inducing receptor AIR, Apo-3, Lymphocyte-associated receptor of death, LARD, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: AAQ88676
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DR3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by DEAE chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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