DR5 (clone 4G12-F5-E9), anti-human

Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Synonyms: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Cellular Location: Membrane Single-pass type I membrane protein

Immunogen:
Purified recombinant human DR5 protein fragments expressed in E.coli.

Gene Symbol: DR5

Gene ID: 8795

Swiss prot: O14763

Calculated MW: 40/48kDa

Recommended dilution:
WB 1:2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.