DR5 (clone 7F4-F8-G11), anti-human, mouse

Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily,and contains an intracellular death domain.This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand(TNFSF10/TRAIL/APO-2L),and transduces an apoptosis signal.Studies with FADD-deficient mice suggested that FADD,a death domain containing adaptor protein,is required for the apoptosis mediated by this protein.Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.[provided by RefSeq,Mar 2009]

Synonyms: CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Cellular Location: Membrane Single-pass type I membrane protein

Immunogen:
Purified recombinant human DR5 protein fragments expressed in E.coli.

Gene Symbol: DR5

Gene ID: 8795

Swiss prot: O14763

Calculated MW: 48kDa

Recommended dilution:
WB 1:500-2000, ICC 1:100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.