DR5 polyclonal, anti-human

Background:
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the "death domain," that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.

Alternative Name:
TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, Fas like protein, Apoptosis inducing protein TRICK2A/2B, Apoptosis inducing receptor TRAIL R2, CD262, CD262 antigen, Cytotoxic TRAIL receptor 2, Death domain containing receptor for TRAIL/Apo 2L, Death receptor 5, DR5, KILLER, KILLER/DR5, OTTHUMP00000123492, OTTHUMP00000123493, p53 regulated DNA damage inducible cell death receptor(killer), TNF related apoptosis inducing ligand receptor 2, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TR10B, TRAIL R2, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, Tumor necrosis factor receptor like protein ZTNFR9, Tumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor receptor superfamily, member 10b, ZTNFR9,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: DR5 polyclonal antibody detects endogenous levels of DR5 protein.

Immunogen:
recombinant protein

MW: 48 kDa

Swiss-Prot: O14763(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.