DRAK2 (I286) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS9183
Background:
DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase contains a “death domain” and has been shown to mediate γ interferon-induced apoptosis. The introduction of DAP kinase into highly metastatic carcinoma clones lacking DAP kinase expression was shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) and DRAK2 are DAP kinase related proteins.
Alternative Name:
DAP kinase related apoptosis inducing protein, DAP kinase related apoptosis inducing protein kinase 2, DAP kinase-related apoptosis-inducing protein kinase 2, Death associated protein kinase related 2, DRAK 2, DRAK2, Serine/threonine kinase 17b, Serine/threonine kinase 17b apoptosis inducing, Serine/threonine protein kinase 17B, Serine/threonine-protein kinase 17B, ST17B, STK 17B, Stk17b,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: DRAK2 (I286) polyclonal antibody detects endogenous levels of DRAK2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 261-310 of Human DRAK2.
MW: ~ 42 kDa
Swis Prot.: O94768
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase contains a “death domain” and has been shown to mediate γ interferon-induced apoptosis. The introduction of DAP kinase into highly metastatic carcinoma clones lacking DAP kinase expression was shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) and DRAK2 are DAP kinase related proteins.
Alternative Name:
DAP kinase related apoptosis inducing protein, DAP kinase related apoptosis inducing protein kinase 2, DAP kinase-related apoptosis-inducing protein kinase 2, Death associated protein kinase related 2, DRAK 2, DRAK2, Serine/threonine kinase 17b, Serine/threonine kinase 17b apoptosis inducing, Serine/threonine protein kinase 17B, Serine/threonine-protein kinase 17B, ST17B, STK 17B, Stk17b,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: DRAK2 (I286) polyclonal antibody detects endogenous levels of DRAK2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 261-310 of Human DRAK2.
MW: ~ 42 kDa
Swis Prot.: O94768
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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