DRAK2 Polyclonal Antibody

Background:
The full-lengthSTK17BcDNA clone encodes a deduced 372-amino acid protein with a molecular mass of 42.34 kD. The putative kinase domain is located at the N terminus and contains all 11 subdomains conserved among ser/thr kinases. STK17A andSTK17Bshare 59.7% amino acid identity.Northern blot analysis revealed that STK17B was expressed in various tissues, such as heart, placenta, liver, and pancreas, as different-sized transcripts, presumably due to differences in the 3-prime untranslated region. Transient transfection of COS-7 cells showed that STK17B localized in nuclei. Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
DAP kinase related apoptosis inducing protein, DAP kinase related apoptosis inducing protein kinase 2, DAP kinase-related apoptosis-inducing protein kinase 2, Death associated protein kinase related 2, DRAK 2, DRAK2, Serine/threonine kinase 17b, Serine/threonine kinase 17b apoptosis inducing, Serine/threonine protein kinase 17B, Serine/threonine-protein kinase 17B, ST17B, STK 17B, Stk17b

Immunogen: Recombinant protein of human STK17B

Swissprot: O94768
Gene Accession: BC016040

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-9639/sc-292771