DRAM(NT) polyclonal, anti-human, mouse, rat antibody
€355.00
In stock
SKU
AC-ABV10816-100
Catalog Number: AC-ABV10816-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, E
Datasheet
Request Information
Background:
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been s µggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and s µggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Other Names:
Damage-regulated autophagy modulator
Primary Accession: Q8N682
Gene Name: DRAM1
Gene ID: 55332
Concentration (mg/ml): 1 mg/ml
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been s µggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and s µggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Other Names:
Damage-regulated autophagy modulator
Primary Accession: Q8N682
Gene Name: DRAM1
Gene ID: 55332
Concentration (mg/ml): 1 mg/ml
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