DROSHA polyclonal, anti-human

Background:
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.

Synonyms: ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN

Cellular Location: Nucleus nucleolus

Immunogen:
A synthetic peptide of human DROSHA

Gene Symbol: DROSHA

Gene ID: 29102

Swiss prot: Q9NRR4

Calculated MW: 159kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.