DRP-2 (phospho-S522) polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS64166
Background:
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule semaphorin 3A/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to semaphorin 3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene is located in 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.
Alternative Name:
Dihydropyrimidinase-related protein 2, DRP2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2
Application Dilution: WB: 1:500~1:1000
Specificity: DRP-2 (phospho-S522) polyclonal antibody detects endogenous levels of DPYSL2 protein only when phosphorylated at Ser522 .
Immunogen:
Synthetic phosphopeptide derived from human DPYSL2 around the phosphorylation site of Serine 522.
MW: ~ 72 kDa
Swis Prot.: Q16555
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule semaphorin 3A/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to semaphorin 3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene is located in 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.
Alternative Name:
Dihydropyrimidinase-related protein 2, DRP2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2
Application Dilution: WB: 1:500~1:1000
Specificity: DRP-2 (phospho-S522) polyclonal antibody detects endogenous levels of DPYSL2 protein only when phosphorylated at Ser522 .
Immunogen:
Synthetic phosphopeptide derived from human DPYSL2 around the phosphorylation site of Serine 522.
MW: ~ 72 kDa
Swis Prot.: Q16555
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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