DSC2 polyclonal, anti-human

Background:
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

Synonyms: ARVD11, CDHF2, DG2, DGII/III, DSC3

Cellular Location: Cell junction Cell membrane Single-pass type I membrane protein desmosome

Immunogen:
Recombinant protein of human DSC2

Gene Symbol: DSC2

Gene ID: 1824

Swiss prot: Q02487

Calculated MW: 100kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.