DSCR1 Polyclonal Antibody

Background:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Research Area: Neuroscience

Synonyms:
Adapt 78, Adapt78, Calcipressin 1, Calcipressin-1, Calcium and oxidant inducible mRNA, CSP 1, CSP1, Down syndrome candidate region 1, Down syndrome critical region gene 1, Down syndrome critical region protein 1, DSC 1, DSC1, DSCR 1, DSCR1, MCIP 1, MCIP1, Modulatory calcineurin interacting protein 1, Myocyte enriched calcineurin interacting protein 1, Myocyte-enriched calcineurin-interacting protein 1, Near DSCR proline rich protein, RCAN1, RCAN1, RCN 1, RCN1, Regulator of calcineurin 1

Immunogen: Synthetic peptide of human RCAN1

Swissprot: P53805
Gene Accession: NP_004405

Calculated MW: 28 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-30589/sc-66864