DSCR2 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6318a
Background:
Down syndrome, the most common birth defect, is characterized by distinct facial and physical features and mental retardation and is caused by trisomy 21. The chromosome region located between DNA marker D21S55 and MX1 in 21q22.3 is referred to as the Down syndrome critical region 2 and is associated with certain features of the syndrome. By searching an EST database for genes between markers D21S343 and D21S268 in Down syndrome critical region 2, Vidal-Taboada et al. (1998) identified DSCR2. Northern blot analysis detects high expression of a 1.3-kb DSCR2 transcript in testis and in the Jurkat leukemia cell line. RT-PCR analysis detects DSCR2 mRNA in brain, colon, leukocytes, breast, and testis, as well as in all fetal tissues tested.
Other Names:
Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, C21-LRP, Down syndrome critical region protein 2, PSMG1, C21LRP, DSCR2, PAC1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6318a was selected from the N-term region of human DSCR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PSMG1
Gene ID: 8624
Primary Accession: O95456
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Down syndrome, the most common birth defect, is characterized by distinct facial and physical features and mental retardation and is caused by trisomy 21. The chromosome region located between DNA marker D21S55 and MX1 in 21q22.3 is referred to as the Down syndrome critical region 2 and is associated with certain features of the syndrome. By searching an EST database for genes between markers D21S343 and D21S268 in Down syndrome critical region 2, Vidal-Taboada et al. (1998) identified DSCR2. Northern blot analysis detects high expression of a 1.3-kb DSCR2 transcript in testis and in the Jurkat leukemia cell line. RT-PCR analysis detects DSCR2 mRNA in brain, colon, leukocytes, breast, and testis, as well as in all fetal tissues tested.
Other Names:
Proteasome assembly chaperone 1, PAC-1, Chromosome 21 leucine-rich protein, C21-LRP, Down syndrome critical region protein 2, PSMG1, C21LRP, DSCR2, PAC1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6318a was selected from the N-term region of human DSCR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PSMG1
Gene ID: 8624
Primary Accession: O95456
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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