DTL polyclonal, anti-mouse, rat
€388.00
In stock
SKU
BS71678
Background:
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
Alternative Name:
CDT2, RAMP, DCAF2, L2DTL
Application Dilution: WB : 1:500 - 1:2000
Specificity: DTL polyclonal antibody detects endogenous levels of DTL protein.
Immunogen:
Recombinant protein of human DTL
MW: Predicted band size: 79 kDa, Observed band size: Refer to Figures
Swis Prot.: Q9NZJ0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.
Alternative Name:
CDT2, RAMP, DCAF2, L2DTL
Application Dilution: WB : 1:500 - 1:2000
Specificity: DTL polyclonal antibody detects endogenous levels of DTL protein.
Immunogen:
Recombinant protein of human DTL
MW: Predicted band size: 79 kDa, Observed band size: Refer to Figures
Swis Prot.: Q9NZJ0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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