DTX2 polyclonal, anti-human, mouse

Background:
DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Synonyms: RNF58

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human DTX2

Gene Symbol: DTX2

Gene ID: 113878

Swiss prot: Q86UW9

Calculated MW: 62/67A

Recommended dilution:
IHC 1:10-50

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.