DTYMK Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7060a
Background:
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
Other Names:
Thymidylate kinase, dTMP kinase, DTYMK, CDC8, TMPK, TYMK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7060a was selected from the N-term region of human DTYMK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DTYMK
Gene ID: 1841
Primary Accession: P23919
Other Accession: NP_036277
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
Other Names:
Thymidylate kinase, dTMP kinase, DTYMK, CDC8, TMPK, TYMK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7060a was selected from the N-term region of human DTYMK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: DTYMK
Gene ID: 1841
Primary Accession: P23919
Other Accession: NP_036277
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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