DUSP14 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60040
Background:
The deduced 198 amino acid MAP kinase phosphatase 6 (MKP-6), also designated MAP6 and dual-specificity phosphatase 14 (DUSP14), is homologous to other MKP family proteins in that it has a conserved, centrally located, catalytic core, but differs from traditional MKP proteins because it contains unique N- and C-terminal regions. Binding and deletion analyses have established that the interaction between the cytoplasmic tail of CD28 (a T cell antigen) and MKP-6 occurs at Tyr 200 of CD28 and is specific for both MKP-6 and CD28; however, Tyr 200 can be mutated to Phe 200 without a loss of binding ability. Functional analysis indicates that MKP-6 dephosphorylates ERK, JNK and p38 while acting as a negative regulator of CD28 signaling. MKP-6 is expressed ubiquitously, although expression is stronger in certain cell types and tissues than in others.
Alternative Name:
Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, MKP-L, Mitogen-activated protein kinase phosphatase 6, MAP kinase phosphatase 6, MKP-6, MKP6
Application Dilution: WB: 1:500~1:1000
Specificity: DUSP14 polyclonal antibody detects endogenous levels of DUSP14 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human DUSP14.
MW: ~ 22 kDa
Swis Prot.: O95147
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The deduced 198 amino acid MAP kinase phosphatase 6 (MKP-6), also designated MAP6 and dual-specificity phosphatase 14 (DUSP14), is homologous to other MKP family proteins in that it has a conserved, centrally located, catalytic core, but differs from traditional MKP proteins because it contains unique N- and C-terminal regions. Binding and deletion analyses have established that the interaction between the cytoplasmic tail of CD28 (a T cell antigen) and MKP-6 occurs at Tyr 200 of CD28 and is specific for both MKP-6 and CD28; however, Tyr 200 can be mutated to Phe 200 without a loss of binding ability. Functional analysis indicates that MKP-6 dephosphorylates ERK, JNK and p38 while acting as a negative regulator of CD28 signaling. MKP-6 is expressed ubiquitously, although expression is stronger in certain cell types and tissues than in others.
Alternative Name:
Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, MKP-L, Mitogen-activated protein kinase phosphatase 6, MAP kinase phosphatase 6, MKP-6, MKP6
Application Dilution: WB: 1:500~1:1000
Specificity: DUSP14 polyclonal antibody detects endogenous levels of DUSP14 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human DUSP14.
MW: ~ 22 kDa
Swis Prot.: O95147
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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