DUSP14 polyclonal (N-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP8456a
Catalog Number: AC-AP8456a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5911
Applications: WB, IHC-P
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5911
Applications: WB, IHC-P
Datasheet
Request Information
Background:
DUSP14 is involved in the inactivation of MAP kinases. This protein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.
Other Names:
Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, MKP-L, Mitogen-activated protein kinase phosphatase 6, MAP kinase phosphatase 6, MKP-6, DUSP14, MKP6
Target/Specificity:
This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP14.
Antigen Region:
1-30
Antigen Type: Synthetic Peptide
Gene Name: DUSP14
Gene ID: 11072
Primary Accession: O95147
NCBI Accession: NP_008957.1
Other Accession: Q9JLY7; Q17QM8
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
DUSP14 is involved in the inactivation of MAP kinases. This protein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.
Other Names:
Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, MKP-L, Mitogen-activated protein kinase phosphatase 6, MAP kinase phosphatase 6, MKP-6, DUSP14, MKP6
Target/Specificity:
This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP14.
Antigen Region:
1-30
Antigen Type: Synthetic Peptide
Gene Name: DUSP14
Gene ID: 11072
Primary Accession: O95147
NCBI Accession: NP_008957.1
Other Accession: Q9JLY7; Q17QM8
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
|---|
Write Your Own Review