DUSP2 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Research Area: Cancer, Cell biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction

Synonyms:
Dual specificity phosphatase 2, Dual specificity protein phosphatase 2, Dual specificity protein phosphatase PAC 1, Dual specificity protein phosphatase PAC-1, DUS2, DUSP 2, DUSP2, PAC 1, PAC1, Serine/threonine specific protein phosphatase

Immunogen: Synthetic peptide of human DUSP2

Swissprot: Q05923
Gene Accession: NP_004409

Calculated MW: 34 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-1621

Citation(s):
https://mcb.asm.org/content/early/2019/02/05/MCB.00391-18.abstract