DUSP22 Polyclonal Antibody

Background:
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.

Research Area: Cell Biology, Signal Transduction

Synonyms:
Dual specificity protein phosphatase 22, DUS22, Dusp22, JNK stimulatory phosphatase 1, JNK-stimulatory phosphatase-1, JSP 1, JSP-1, JSP1, LMW DSP2, LMW-DSP2, Low molecular weight dual specificity phosphatase 2, MAP kinase phosphatase x, Mitogen activated protein kinase phosphatase x, Mitogen-activated protein kinase phosphatase x, MKP-x, MKPX

Immunogen: Recombinant protein of human DUSP22

Swissprot: Q9NRW4
Gene Accession: BC016844

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-47935