DUSP3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
DUSP3(Dual-specificity phosphatase 3), also called VHR, is a member of the dual specificity protein phosphatase subfamily. DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP3 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP(mitogen-activated protein kinase phosphatase) class of DUSPs. The DUSP3 gene is mapped on 17q21.31. Confocal microscopy demonstrated that phosphorylated VHR accumulated at the immune synapse between the T cell and the antigen-presenting cell in the presence of antigen. Tyrosine phosphorylation of VHR affects protein-protein interaction, subcellular location, or substrate targeting, given that tyr138 is located on the opposite side of the VHR catalytic center.

Description:
Rabbit IgG polyclonal antibody for Dual specificity protein phosphatase 3 (DUSP3) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Dual specificity phosphatase 3 antibody, Dual specificity protein phosphatase 3 antibody, Dual specificity protein phosphatase VHR antibody, DUS3_HUMAN antibody, DUSP3 antibody, Serine/threonine specific protein phosphatase antibody, Vaccinia H1-related phosphatase antibody, Vaccinia virus phosphatase VH1 related antibody, VHR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human DUSP3(155-171aa RQNREIGPNDGFLAQLC), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human DUSP3(155-171aa RQNREIGPNDGFLAQLC), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.