DUSP7 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP14393c
Background:
Dual-specificity phosphatases (DUSPs) constitute a largeheterogeneous subgroup of the type I cysteine-basedprotein-tyrosine phosphatase superfamily. DUSPs are characterizedby their ability to dephosphorylate both tyrosine andserine/threonine residues. DUSP7 belongs to a class of DUSPs,designated MKPs, that dephosphorylate MAPK (mitogen-activatedprotein kinase) proteins ERK (see MIM 601795), JNK (see MIM601158), and p38 (see MIM 600289) with specificity distinct fromthat of individual MKP proteins. MKPs contain a highly conservedC-terminal catalytic domain and an N-terminal Cdc25 (see MIM116947)-like (CH2) domain. MAPK activation cascades mediate variousphysiologic processes, including cellular proliferation, apoptosis,differentiation, and stress responses (summary by Patterson et al.,2009 [PubMed 19228121]).
Other Names:
Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2
Gene Name: DUSP7 (HGNC:3073)
Gene ID: 1849
Primary Accession: Q16829
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Dual-specificity phosphatases (DUSPs) constitute a largeheterogeneous subgroup of the type I cysteine-basedprotein-tyrosine phosphatase superfamily. DUSPs are characterizedby their ability to dephosphorylate both tyrosine andserine/threonine residues. DUSP7 belongs to a class of DUSPs,designated MKPs, that dephosphorylate MAPK (mitogen-activatedprotein kinase) proteins ERK (see MIM 601795), JNK (see MIM601158), and p38 (see MIM 600289) with specificity distinct fromthat of individual MKP proteins. MKPs contain a highly conservedC-terminal catalytic domain and an N-terminal Cdc25 (see MIM116947)-like (CH2) domain. MAPK activation cascades mediate variousphysiologic processes, including cellular proliferation, apoptosis,differentiation, and stress responses (summary by Patterson et al.,2009 [PubMed 19228121]).
Other Names:
Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2
Gene Name: DUSP7 (HGNC:3073)
Gene ID: 1849
Primary Accession: Q16829
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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