DUSP8 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP8451b
Catalog Number: AC-AP8451b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5874
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5874
Applications: IHC-P, WB
Datasheet
Request Information
Background:
DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
Other Names:
Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5
Target/Specificity:
This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.
Antigen Region:
456-487
Antigen Type: Synthetic Peptide
Gene Name: DUSP8
Gene ID: 1850
Primary Accession: Q13202
NCBI Accession: NP_004411.2
Other Accession: NP_004411
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
Other Names:
Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5
Target/Specificity:
This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.
Antigen Region:
456-487
Antigen Type: Synthetic Peptide
Gene Name: DUSP8
Gene ID: 1850
Primary Accession: Q13202
NCBI Accession: NP_004411.2
Other Accession: NP_004411
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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