DUT Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14203b
Background:
This gene encodes an essential enzyme of nucleotidemetabolism. The encoded protein forms a ubiquitous, homotetramericenzyme that hydrolyzes dUTP to dUMP and pyrophosphate. Thisreaction serves two cellular purposes: providing a precursor (dUMP)for the synthesis of thymine nucleotides needed for DNAreplication, and limiting intracellular pools of dUTP. Elevatedlevels of dUTP lead to increased incorporation of uracil into DNA,which induces extensive excision repair mediated by uracilglycosylase. This repair process, resulting in the removal andreincorporation of dUTP, is self-defeating and leads to DNAfragmentation and cell death. Alternative splicing of this geneleads to different isoforms that localize to either themitochondrion or nucleus. A related pseudogene is located onchromosome 19.
Other Names:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Gene Name: DUT
Gene ID: 1854
Primary Accession: P33316
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes an essential enzyme of nucleotidemetabolism. The encoded protein forms a ubiquitous, homotetramericenzyme that hydrolyzes dUTP to dUMP and pyrophosphate. Thisreaction serves two cellular purposes: providing a precursor (dUMP)for the synthesis of thymine nucleotides needed for DNAreplication, and limiting intracellular pools of dUTP. Elevatedlevels of dUTP lead to increased incorporation of uracil into DNA,which induces extensive excision repair mediated by uracilglycosylase. This repair process, resulting in the removal andreincorporation of dUTP, is self-defeating and leads to DNAfragmentation and cell death. Alternative splicing of this geneleads to different isoforms that localize to either themitochondrion or nucleus. A related pseudogene is located onchromosome 19.
Other Names:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Gene Name: DUT
Gene ID: 1854
Primary Accession: P33316
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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