DUT antibody (clone 1C9), anti-human
€435.00
In stock
SKU
AC-AT1831a
Catalog Number: AC-AT1831a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT1831a">Request Information
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT1831a">Request Information
Background:
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Other Names:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Antigen Type:
Recombinant Protein
Gene Name: DUT
Gene ID: 1854
NCBI Accession: NP_001020419.1;NP_001020420.1;NP_001939.1
Primary Accession: P33316
Other Accession: BC033645
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Other Names:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Antigen Type:
Recombinant Protein
Gene Name: DUT
Gene ID: 1854
NCBI Accession: NP_001020419.1;NP_001020420.1;NP_001939.1
Primary Accession: P33316
Other Accession: BC033645
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review