DYL1 Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1|200 kD. They contain two force-producing heads formed primarily from dynein heavy chains| and stalks linking the heads to a basal domain| which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer| a conformation necessary for activity| and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Research Area: Cancer, Cell biology, Epigenetics and nuclear signaling, Metabolism, Neuroscience, Signal transduction

Synonyms: DYL1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year