Dynactin 2 polyclonal, anti-human, mouse, rat

Background:
Dynactin 2, also known as DCTN2, Dynamitin or DCTN50, is a peripheral membrane protein that is one of many subunits in the Dynactin complex. Like other Dynactin subunits, Dynactin 2 mediates Dynein-organelle binding and helps to regulate chromosome alignment during prometaphase and spindle organization during mitosis. Overexpression of Dynactin 2 disrupts the Dynactin-Dynein complex, thus inhibiting retrograde axonal transport and causing motor neuron degeneration.

Alternative Name:
Dynactin subunit 2, 50 kDa dynein-associated polypeptide, Dynactin complex 50 kDa subunit, DCTN-50, p50 dynamitin, DCTN2, DCTN50

Application Dilution: WB: 1:500~1:2000

Specificity: Dynactin 2 polyclonal antibody detects endogenous levels of Dynactin 2 protein.

Immunogen:
Recombinant full length Human Dynactin 2 / DCTN2.

MW: ~ 44 kDa

Swis Prot.: Q13561

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.