Dynamin 1 polyclonal, anti-human, mouse, rat

Background:
Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity). The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.

Alternative Name:
DNM1, DNM, B dynamin, D100, DNM 1, DNM, DNM1, DYN1, Dynamin, Dynamin-1, Dynamin1,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200

Specificity: Dynamin 1 polyclonal antibody detects endogenous levels of Dynamin 1 protein.

Immunogen:
Recombinant protein within human Dynamin 1 aa 575-750.

MW: 97 kDa

Swiss-Prot: Q05193(Human) P39053(Mouse) P21575(Rat)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.