Dynamin 2 polyclonal, anti-human

Background:
Members of the dynamin family, including Dynamin I and Dynamin II, are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.

Alternative Name:
DNM2, DYN2, CMT2M, CMTDI1, CMTDIB, DI CMTB, Dnm2, DYN II, DYN2, DYN2, Dynamin II, Dynamin-2, Dynamin2, DynaminII, DYNII,

Application Dilution:
WB:1:500-1:1,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Dynamin 2 polyclonal antibody detects endogenous levels of Dynamin 2 protein.

Immunogen:
Recombinant protein

MW: 98 kDa

Swiss-Prot: P50570(Human) P39054(Mouse) P39052(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.