DYNC2LI1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Synonyms: CGI-60, D2LIC, LIC3

Cellular Location: Cytoplasm cilium axoneme cytoskeleton

Immunogen:
Recombinant protein of human DYNC2LI1

Gene Symbol: DYNC2LI1

Gene ID: 51626

Swiss prot: Q8TCX1

Calculated MW: 40kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.