DYNLL1 polyclonal, anti-human, mouse, rat

Background:
Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors, the complex transports cellular cargos towards the central region of the cell. The highly conserved DYNLL proteins were originally identified as light chains for microtubule-based motor protein Dynein. In mammals there are two closely related isoforms expressed, DYNLL1 and DYNLL2 which share 93% sequence identity at the protein level. DYNLL1 (Dynein light chain 1) also designated, DLC8 or PIN (Protein inhibitor of neuronal nitric oxide synthase) has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Dimerization is required for NOS1 activity and DYNLL1 has been shown to destabilize the NOS1 dimer. Nitric oxide may be involved in several processes such as apoptosis, synaptogenesis and neuronal development, thus DYNLL1 is implicated in these processes as well. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain.

Alternative Name:
DLC8, PIN, DYNLL1, 8 kDa dynein light chain, 8kDLC, Cytoplasmic dynein light polypeptide, DLC1, DLC8, DNCL1, DNCLC1, DYL1, Dynein , cytoplasmic, light chain 1, Dynein light chain 1 cytoplasmic, Dynein light chain 1, cytoplasmic, Dynein light chain LC8 type 1, Dynein light chain LC8-type 1, Dynein, cytoplasmic, light polypeptide 1, Dynein, light chain, LC8-type 1, DYNLL1, HDLC1, LC8, LC8a, MGC126137, MGC126138, MGC72986, PIN, Protein inhibitor of neuronal nitric oxide synthase, Protein inhibitor of neuronal NOS,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: DYNLL1 polyclonal antibody detects endogenous levels of DYNLL1 protein.

Immunogen:
recombinant protein

MW: 10 kDa

Swiss-Prot: P63167(Human) P63168(Mouse) P63170(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.