DYRK1A polyclonal (N-term), anti-human, mouse
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In stock
SKU
AC-AP7555a
Catalog Number: AC-AP7555a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13055
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13055
Applications: WB, IHC-P
Datasheet
Request Information
Background:
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Other Names:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH
Target/Specificity:
This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Antigen Region:
107-136
Antigen Type: Synthetic Peptide
Gene Name: DYRK1A {ECO:0000303|PubMed:25620562, ECO:0000312|HGNC:HGNC:3091}
Gene ID: 1859
Primary Accession: Q13627
NCBI Accession: NP_001387.2;NP_567824.1;NP_569120.1;NP_569122.1
Other Accession: Q2TAE3; Q63470; Q61214
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Other Names:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH
Target/Specificity:
This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Antigen Region:
107-136
Antigen Type: Synthetic Peptide
Gene Name: DYRK1A {ECO:0000303|PubMed:25620562, ECO:0000312|HGNC:HGNC:3091}
Gene ID: 1859
Primary Accession: Q13627
NCBI Accession: NP_001387.2;NP_567824.1;NP_569120.1;NP_569122.1
Other Accession: Q2TAE3; Q63470; Q61214
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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