Dysadherin polyclonal, anti-human

Quantity: 100 µg

Background:
FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.

Description:
Rabbit IgG polyclonal antibody for FXYD domain-containing ion transport regulator 5 (FXYD5) detection. Tested with WB, IHC-P in Human.

Synonyms:
Dysad antibody, Dysadherin antibody, FXYD 5 antibody, FXYD domain containing ion transport regulator 5 antibody, FXYD domain-containing ion transport regulator 5 antibody, Fxyd5 antibody, FXYD5_HUMAN antibody, FXYD5RIC antibody, HSPC 113 antibody, HSPC113 antibody, IWU 1 antibody, IWU1 antibody, KCT 1 antibody, KCT1 antibody, Keratinocytes associated transmembrane protein 1 antibody, OIT 2 antibody, OIT2 antibody, PRO 6241 antibody, PRO6241 antibody, RIC antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin(165-188aa KCRQLSRLCRNRCR).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.