E-Cadherin (CDH1) monoclonal, anti-human
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In stock
SKU
BMA1048
Catalog Number: BMA1048
Size: 100 μg
Isotype: Rabbit IgG
Reactivity: human
Application(s): WB, IHC-P, ICC/IF, Flow-Cyt
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Size: 100 μg
Isotype: Rabbit IgG
Reactivity: human
Application(s): WB, IHC-P, ICC/IF, Flow-Cyt
Request Information
Background:
Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene.1E-cadherin is a Ca(2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. It has 16 exons spanning approximately 100 kb of genomic DNA. The gene structure is similar to that of other cadherins.2E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression.3
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to the region ofhuman E-cadherin.
Recommended Application:
Western Blot, WB(1:200-1:500); Immunohistochemistry, IHC-P(1:20-1:100); Immunocytochemistry, ICC/IF (1:20-1:100); Flow Cytometry, Flow-Cyt (1:20-1:50)
Product Form: Liquid
Purification: Protein A affinity purified
Storage Buffer: 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene.1E-cadherin is a Ca(2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. It has 16 exons spanning approximately 100 kb of genomic DNA. The gene structure is similar to that of other cadherins.2E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression.3
Immunogen:
A synthetic peptide (conjugated with KLH) corresponding to the region ofhuman E-cadherin.
Recommended Application:
Western Blot, WB(1:200-1:500); Immunohistochemistry, IHC-P(1:20-1:100); Immunocytochemistry, ICC/IF (1:20-1:100); Flow Cytometry, Flow-Cyt (1:20-1:50)
Product Form: Liquid
Purification: Protein A affinity purified
Storage Buffer: 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
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