Cdc20 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP68974
Background:
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Other Names:
CDC20; Cell division cycle protein 20 homolog; p55CDC
Antigen Type: synthetic peptide
Antigen Type: CDC20
Gene ID: 991
Primary Accession: Q12834
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Other Names:
CDC20; Cell division cycle protein 20 homolog; p55CDC
Antigen Type: synthetic peptide
Antigen Type: CDC20
Gene ID: 991
Primary Accession: Q12834
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