E-cadherin Polyclonal Antibody

Background:
cadherin 1(CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],

Alternative Names:
CDH1, CDHE, UVO, Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324

Immunogen: Recombinant Protein of E-cadherin

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Observed band: 125-130

GeneID: CDH1

Storage: -20°C/1 year

NOTE: For Research Use Only