E-Ras rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012],enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PIK3CD.,

Synonyms: ERAS, HRAS2, HRASP, GTPase ERas, E-Ras, Embryonic stem cell-expressed Ras

Gene Name: ERAS

Gene ID: 3266

SwissProt ID: Q7Z444

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.