E2F4 antibody (clone 5B7), anti-human
€435.00
In stock
SKU
AC-AT1836a
Catalog Number: AC-AT1836a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
Request Information AC-AT1836a">Request Information
Background:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Other Names:
Transcription factor E2F4, E2F-4, E2F4
Antigen Type:
Recombinant Protein
Gene Name: E2F4
Gene ID: 1874
NCBI Accession: NP_001941.2
Primary Accession: Q16254
Other Accession: NM_001950
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Other Names:
Transcription factor E2F4, E2F-4, E2F4
Antigen Type:
Recombinant Protein
Gene Name: E2F4
Gene ID: 1874
NCBI Accession: NP_001941.2
Primary Accession: Q16254
Other Accession: NM_001950
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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