E2F4 Polyclonal Antibody

Background:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
E2F 4, E2F transcription factor 4, E2F transcription factor 4 p107/p130 binding, E2F-4, E2F4, E2F4, p107/p130 binding protein, Transcription factor E2F 4, Transcription factor E2F4

Immunogen: Synthetic peptide of human E2F4

Swissprot: Q16254
Gene Accession: NP_001941

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-866/sc-1082/sc-512