E2F6 antibody (clone 2B6-G9), anti-human
€435.00
In stock
SKU
AC-AT1837a
Catalog Number: AC-AT1837a
Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2a kappa
Applications: WB
Request Information AC-AT1837a">Request Information
Background:
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
Other Names:
Transcription factor E2F6, E2F-6, E2F6
Antigen Type:
Recombinant Protein
Gene Name: E2F6 {ECO:0000303|PubMed:9689056, ECO:0000312|HGNC:HGNC:3120}
Gene ID: 1876
NCBI Accession: NP_001265204.1;NP_001265205.1;NP_001265206.1;NP_001265207.1;NP_937987.2
Primary Accession: O75461
Other Accession: BC008348
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
Other Names:
Transcription factor E2F6, E2F-6, E2F6
Antigen Type:
Recombinant Protein
Gene Name: E2F6 {ECO:0000303|PubMed:9689056, ECO:0000312|HGNC:HGNC:3120}
Gene ID: 1876
NCBI Accession: NP_001265204.1;NP_001265205.1;NP_001265206.1;NP_001265207.1;NP_937987.2
Primary Accession: O75461
Other Accession: BC008348
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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