EAAT3 polyclonal, anti-human, mouse, rat

Background:
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na+ symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Negatively regulated by ARL6IP5.

Alternative Name:
SLC1A1, EAAC1, EAAT3, EAA3, EAAC 1, EAAC1, EAAT 3, Excitatory amino acid carrier 1, Excitatory amino acid carrier1, Excitatory amino acid transporter 3, Excitatory amino acid transporter3, Excitatory amino-acid carrier 1, GLUTAMATE TRANSPORTER, HIGH-AFFINITY, MEAAC 1, MEAAC1, Neuronal and epithelial glutamate transporter, REAAC 1, REAAC1, Slc1 a1, Slc1a 1, SLC1A1, Sodium dependent glutamate/aspartate transporter 3, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter, system Xag), member 1, SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER), MEMBER 1, Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1, Solute carrier family 1 member 1, Solute carrier family 1, member 1,

Application Dilution:
WB:1:500
ICC/IF:1:50-1:200
IHC:1:50-1:200

Specificity: EAAT3 polyclonal antibody detects endogenous levels of EAAT3 protein.

Immunogen:
Recombinant protein

MW: 57 kDa (Predicted band size)

Swiss-Prot: P43005(Human) P51906(Mouse) P51907(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.