EB1 (clone KT51), anti-human, mouse, monkey, other

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signal Transduction, Cell Motility

Description:
EB proteins belong to the microtubule plus end tracking family proteins. They interact with cytoplasmic microtubules in interphase cells, with mitotic spindles, and with the adenomatous polyposis coli (APC) tumor suppressor. The end-binding protein 1, 2 and 3 (EB1-3) are involved in microtubule polymerization and stabilization with centrosomes as well as spindle function. The N-terminal domain of EB proteins binds to microtubules whereas the C-terminal domain forms mutually exclusive complexes with APC and DCTN1. This antibody recognizes the human, monkey, mouse and hamster EB1 in ELISA, Western blot, immunoprecipitation and immunofluorescent staining.

Alternate Names: Microtubule-associated protein RP/EB family member 1, End-binding protein 1, EB1, APC-binding protein EB1, MAPRE1

Application Notes: WB: 1:2,000; IF: 1:200

Accession No.: Q15691, NP_036457

Antigen: Recombinant human EB1[125-268]-GST fusion protein

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.