EB3 polyclonal, anti-human, mouse, rat

Background:
EB1 (MAPRE2, microtubule-associated protein, RP/EB family, member 2, EB2, RP1) may influence tumorigenesis of colorectal cancers and proliferative control of normal cells. EB1 may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Colorectal cancer is caused by the pathologic transformation of normal colonic epithelium to an adenomatous polyp, which can become an invasive cancer. APC (adenomatous polyposis coli) is a tumor suppressor gene, the mutation of which is one of the earliest events in colorectal carcinogenesis. A majority of the mutations result in the loss of the carboxy terminus of APC. EB1 has been shown to bind to the carboxy terminal region of APC, which implicates EB1 in APC suppression of colonic cancer. EB1 overexpression may play a role in the development of human esophageal squamous cell carcinoma (ESCC) by affecting APC function and activating the beta-catenin/TCF pathway. EB3 is related to EB1 and likewise associates with the microtubule cytoskeleton. EB3 is expressed predominantly in the central nervous system and preferentially associates with APCL.

Alternative Name:
EBF3, EB3, MAPRE3, APC binding protein, EB 3, EB1 protein family member 3, EB3, EBF 3, EBF3, EBF3 S, End binding protein 3, End-binding protein 3, MAPRE 3, MAPRE3, MARE3, Member 3, Microtubule Associated Protein, Microtubule associated protein RP/EB family member 3, Microtubule-associated protein RP/EB family member 3, OTTHUMP00000200910, RP 3, RP/EB Family, RP3,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: EB3 polyclonal antibody detects endogenous levels of EB3 protein.

Immunogen:
Recombinant protein

MW: 32 kDa

Swiss-Prot: Q9UPY8(Human) Q6PER3(Mouse) Q5XIT1(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.